If you are moving up more then 1 level, the answer is yes!
My co-worker, Mark Duthoy, wrote a blog today about cutting new remote databases when upgrading to SalesLogix v7.5. I think this is a great article for SalesLogix Admins and should be a part of everyone's SalesLogix best practices. This is what he wrote:
"There has been some recent discussion on the need for cutting new remote databases after upgrading. There are typically a number of database schema changes with each upgrade that would require a longer then usual synchronization to transfer to remote users. Any upgrade from version 6.x to 7.5 is actually an upgrade to 3 levels higher and a new db is mandatory for each remote user. Would I create a new remote db for users if upgrading from 7.0 to 7.5? Definitely - you are moving up 2 levels and there are significant schema changes that would warrant new databases rather then a reliance on synchronization. As a general guideline I would only rely on synchronization to send schema from one level to the next i.e. from version 7.0 to version 7.2. On the plus side of the newer versions, the attach remote functionality has improved considerably and is now really quick. I know SalesLogix Admins cringe when they are required to cut new databases but it is an opportunity to touch base with all of your remote users."
I hope this information is helpful!
-Brianna